Seminars & Lectures
| * TITLE | The Elastic Theories of Membranes and Single Molecule DNA/RNA and Their Biological Effects | ||||||
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| * DATE / TIME | 2006-08-28, 10:00 a.m. ~ 11:00 a.m. | ||||||
| * PLACE | Seminar room #512, APCTP Headquarters | ||||||
| * ABSTRACT | |||||||
| In this talk we first report recent progress on elasticity of fluid membranes. The equilibrium shape equation of closed vesicle is developed to vesicle with hole. The application of the shape equation to dynamics of vesicle and to the measurement of single cell shape is also discussed. The elastic responses of double-(ds) and single-stranded(ss) DNA/RNA are also reported briefly. A recent study on the stress-induced local denaturation (or local melting) of dsDNA with Benham model and related biological effects in bioinformatics is introduced in more details. We developed a novel and fast algorithm, the generating function approach, to calculate the denature of DNA sequences longer than 10 kb. To consider the relation with eukaryotic genetics we use the method to investigate the melting behavior of covalently-closed dsDNA . We investigate local melting probability for a given sequence-dsDNA. Comparing with several eukaryotic DNA sequences we found the long-range allosteric effect on molecule DNA to be related to chromatin looping structure, a factor in gene transcriptional regulation, e.g., it can be used to predict the eukaryotic scaffold/matrix attachment regions (SMARs). Therefore, this gives evidence that dsDNA is not only an information carrier (the sequence) but also a stage variable with the gene regulation. | |||||||
