Seminars & Lectures
| * TITLE | Anti-inflammatory cells in the gut | ||||||
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| * DATE / TIME | 2014-06-19 | ||||||
| * PLACE | APCTP Headquarters, Seminar room(512) | ||||||
| * ABSTRACT | |||||||
| Although it has been recently highlighted that the small intestinal lamina propria (LP) serves both effector (IgA secretion and Th17) and regulator (oral tolerance and Treg) functions in the mucosal immune systems, it remains elusive how these apparently opposing functions are regulated in situ. Intestinal LP antigen presenting cells such as dendritic cells (DCs), macrophages and eosinophils (EOs) are cardinal constituents of the mucosal immune system and play pivotal roles in the induction and maintenance of antigen-specific immune responses. Especially, F4/80+ cells including EOs (MBP+) and macrophages (CX3CR1+) are abundant in the small intestinal LP, where they appear to act as sentinels for incoming luminal antigens. We found that LP-EOs inhibited differentiation of Th17 cells from LP-derived CD4+ T cells, whereas LP-DCs were inefficient in suppressing Th17 cell differentiation. On the other hand, intestinal CX3CR1+ cells are able to induce a phenotypically unique population of Tregs expressing CD103 and Helios in the small intestine that exhibit augmented suppressive activity in the food allergy model. We will discuss how intestinal F4/80+ innate immune cells regulate inflammatory Th17 cells and Tregs under various conditions. |
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