Seminars & Lectures
| * TITLE | A theoretical approach to study boundary morphogenesis in developing tissues | ||||||
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| * DATE / TIME | 2015-02-26, 16:00pm | ||||||
| * ABSTRACT | |||||||
| An interesting feature of many biological tissues is their distinct organization into different populations of cells. Boundaries between different populations play critical roles in development of tissues by separating populations and acting as a center of signaling networks. In this talk, I would like to discuss our theoretical models to investigate how boundaries are shaped in developing tissues. First I focus on boundaries in plant tissues and specifically present our understanding of the boundaries between teeth and margin in leaves. Our model takes into account the interactions of the gene regulatory network in the vicinity of the boundary. I discuss how we use experimental measurements to improve our model. Our analysis allows us to propose possible scenarios to establish distinct domains at two sides of boundaries. These scenarios can account for time evolution of the observed aspects of tooth formation. In the second part, I introduce a physical framework which accounts for cell mechanics as well as tissue growth in a continuum description or a cell-level vertex model. With the help of these models we can investigate some general features of dynamics and mechanisms of compartment boundaries in developing epithelia. For instance, the continuum model allows us to study the propagation of interfaces due to the interplay of cell dynamics and tissue mechanics. We also use the vertex model to analyze the general physical mechanisms which control shape of compartment boundaries during the growth phase. |
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